PPARγ is an E3 ligase that induces the degradation of NFκB/p65
PPARγ is an E3 ligase that induces the degradation of NFκB/p65
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Nuclear factor-κB (NFκB) and peroxisome proliferator activated receptor-γ (PPARγ) are both transcription factors that perform distinct but overlapping roles in cellular regulation. Here we report that PPARγ acts as an E3 ubiquitin ligase, physically interacting with p65 to induce its ubiquitination and degradation. The ligand-binding domain of PPAR...
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Full title
PPARγ is an E3 ligase that induces the degradation of NFκB/p65
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TN_cdi_proquest_miscellaneous_1273304355
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1273304355
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms2270
