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Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of hetero...

Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of hetero...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1273346501

Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins

About this item

Full title

Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins

Publisher

United States

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2012-12, Vol.109 (52), p.21366

Language

English

Formats

Publication information

Publisher

United States

More information

Scope and Contents

Contents

129/SvEv mice with a loss-of-function mutation in the heterotrimeric G protein α-subunit gene Gnai3 have fusions of ribs and lumbar vertebrae, indicating a requirement for Gα(i) (the "inhibitory" class of α-subunits) in somite derivatives. Mice with mutations of Gnai1 or Gnai2 have neither defect, but loss of both Gnai3 and one of the other two gen...

Alternative Titles

Full title

Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1273346501

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1273346501

Other Identifiers

ISSN

1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.1219810110

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