Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of hetero...
Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins
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United States
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English
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United States
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129/SvEv mice with a loss-of-function mutation in the heterotrimeric G protein α-subunit gene Gnai3 have fusions of ribs and lumbar vertebrae, indicating a requirement for Gα(i) (the "inhibitory" class of α-subunits) in somite derivatives. Mice with mutations of Gnai1 or Gnai2 have neither defect, but loss of both Gnai3 and one of the other two gen...
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Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins
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TN_cdi_proquest_miscellaneous_1273346501
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1273346501
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ISSN
1091-6490
E-ISSN
1091-6490
DOI
10.1073/pnas.1219810110