SLC4A2-mediated Cl⁻/HCO₃⁻ exchange activity is essential for calpain-dependent regulation of the act...
SLC4A2-mediated Cl⁻/HCO₃⁻ exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Bone remodeling requires osteoclasts to generate and maintain an acidified resorption compartment between the apical membrane and the bone surface to solubilize hydroxyapatite crystals within the bone matrix. This acidification process requires (i) apical proton secretion by a vacuolar H ⁺-ATPase, (ii) actin cytoskeleton reorganization into a podos...
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Full title
SLC4A2-mediated Cl⁻/HCO₃⁻ exchange activity is essential for calpain-dependent regulation of the actin cytoskeleton in osteoclasts
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TN_cdi_proquest_miscellaneous_1285082523
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1285082523
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1206392110
