Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression altera...
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
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Author / Creator
Schug, Markus , Stöber, Regina , Heise, Tanja , Mielke, Hans , Gundert-Remy, Ursula , Godoy, Patricio , Reif, Raymond , Blaszkewicz, Meinolf , Ellinger-Ziegelbauer, Heidrun , Ahr, Hans-Jürgen , Selinski, Silvia , Günther, Georgia , Marchan, Rosemarie , Sachinidis, Agapios , Nüssler, Andreas , Oberemm, Axel and Hengstler, Jan G.
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
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Publisher
Berlin/Heidelberg: Springer-Verlag
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Contents
Cultivated hepatocytes represent a well-established in vitro system. However, the applicability of hepatocytes in toxicogenomics is still controversially discussed. Recently, an in vivo/in vitro discrepancy has been described, whereby the non-genotoxic rat liver carcinogen methapyrilene alters the expression of the metabolizing genes SULT1A1 and AB...
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Full title
Pharmacokinetics explain in vivo/in vitro discrepancies of carcinogen-induced gene expression alterations in rat liver and cultivated hepatocytes
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Author / Creator
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Record Identifier
TN_cdi_proquest_miscellaneous_1291608262
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1291608262
Other Identifiers
ISSN
0340-5761
E-ISSN
1432-0738
DOI
10.1007/s00204-012-0999-8
