Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5
Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5
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Author / Creator
Noda, Kazuo , Dabovic, Branka , Takagi, Kyoko , Inoue, Tadashi , Horiguchi, Masahito , Hirai, Maretoshi , Fujikawa, Yusuke , Akama, Tomoya O. , Kusumoto, Kenji , Zilberberg, Lior , Sakai, Lynn Y. , Koli, Katri , Naitoh, Motoko , von Melchner, Harald , Suzuki, Shigehiko , Rifkin, Daniel B. and Nakamura, Tomoyuki
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Elastic fiber assembly requires deposition of elastin monomers onto microfibrils, the mechanism of which is incompletely understood. Here we show that latent TGF-β binding protein 4 (LTBP-4) potentiates formation of elastic fibers through interacting with fibulin-5, a tropoelastin-binding protein necessary for elastogenesis. Decreased expression of...
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Full title
Latent TGF-β binding protein 4 promotes elastic fiber assembly by interacting with fibulin-5
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Record Identifier
TN_cdi_proquest_miscellaneous_1312173995
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1312173995
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1215779110
