Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal ade...
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
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Author / Creator
The WGS500 Consortium , The CORGI Consortium , WGS500 Consortium , CORGI Consortium , Palles, Claire , Cazier, Jean-Baptiste , Howarth, Kimberley M , Domingo, Enric , Jones, Angela M , Broderick, Peter , Kemp, Zoe , Spain, Sarah L , Guarino, Estrella , Salguero, Israel , Sherborne, Amy , Chubb, Daniel , Carvajal-Carmona, Luis G , Ma, Yusanne , Kaur, Kulvinder , Dobbins, Sara , Barclay, Ella , Gorman, Maggie , Martin, Lynn , Kovac, Michal B , Humphray, Sean , Lucassen, Anneke , Holmes, Christopher C , Bentley, David , Donnelly, Peter , Taylor, Jenny , Petridis, Christos , Roylance, Rebecca , Sawyer, Elinor J , Kerr, David J , Clark, Susan , Grimes, Jonathan , Kearsey, Stephen E , Thomas, Huw J W , McVean, Gilean , Houlston, Richard S and Tomlinson, Ian
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Ian Tomlinson and colleagues report the identification of germline variants in
POLE
and
POLD1
that are susceptibility alleles for colorectal cancer.
POLE
and
POLD1
encode DNA polymerases that function in DNA replication.
Many individuals with multiple or large colorectal adenomas or early-onset colorectal cancer (CRC) hav...
Alternative Titles
Full title
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas
Authors, Artists and Contributors
Author / Creator
The CORGI Consortium
WGS500 Consortium
CORGI Consortium
Palles, Claire
Cazier, Jean-Baptiste
Howarth, Kimberley M
Domingo, Enric
Jones, Angela M
Broderick, Peter
Kemp, Zoe
Spain, Sarah L
Guarino, Estrella
Salguero, Israel
Sherborne, Amy
Chubb, Daniel
Carvajal-Carmona, Luis G
Ma, Yusanne
Kaur, Kulvinder
Dobbins, Sara
Barclay, Ella
Gorman, Maggie
Martin, Lynn
Kovac, Michal B
Humphray, Sean
Lucassen, Anneke
Holmes, Christopher C
Bentley, David
Donnelly, Peter
Taylor, Jenny
Petridis, Christos
Roylance, Rebecca
Sawyer, Elinor J
Kerr, David J
Clark, Susan
Grimes, Jonathan
Kearsey, Stephen E
Thomas, Huw J W
McVean, Gilean
Houlston, Richard S
Tomlinson, Ian
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1316057125
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1316057125
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2503
