Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells
Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
CD8
+
T cell are primed via recognition of cognate peptides presented by APCs. Krummel and colleagues show that optimal CD8
+
T cell differentiation then occurs via T cell–T cell interactions dependent on the integrin LFA-1.
Immunization results in the differentiation of CD8
+
T cells, such that they acquire effector abilities...
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Full title
Secondary T cell–T cell synaptic interactions drive the differentiation of protective CD8+ T cells
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TN_cdi_proquest_miscellaneous_1318103707
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1318103707
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ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/ni.2547
