The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells
The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The ATM motif was previously shown to phosphorylate the BH3-only BID protein, a pro-apoptotic member of the BCL2 family. Using transgenic mice expressing a phosphodefective BID, Gross and colleagues find that the ATM effect on BID prevents its translocation to the mitochondria, where the effects of BID on ROS would trigger haematopoietic stem cells...
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Full title
The ATM–BID pathway regulates quiescence and survival of haematopoietic stem cells
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TN_cdi_proquest_miscellaneous_1318694771
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1318694771
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2468
