Managing the challenge of chemically reactive metabolites in drug development
Managing the challenge of chemically reactive metabolites in drug development
About this item
Full title
Author / Creator
Park, B. Kevin , Boobis, Alan , Clarke, Stephen , Goldring, Chris E. P. , Jones, David , Kenna, J. Gerry , Lambert, Craig , Laverty, Hugh G. , Naisbitt, Dean J. , Nelson, Sidney , Nicoll-Griffith, Deborah A. , Obach, R. Scott , Routledge, Philip , Smith, Dennis A. , Tweedie, Donald J. , Vermeulen, Nico , Williams, Dominic P. , Wilson, Ian D. and Baillie, Thomas A.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Key Points
Metabolism of drugs can generate metabolites that are chemically reactive towards cellular molecules and have the potential to alter biological function and initiate serious adverse drug reactions.
This Review details methods for the detection of chemically reactive metabolites (CRMs), and outlines the current industrial and academ...
Alternative Titles
Full title
Managing the challenge of chemically reactive metabolites in drug development
Authors, Artists and Contributors
Author / Creator
Boobis, Alan
Clarke, Stephen
Goldring, Chris E. P.
Jones, David
Kenna, J. Gerry
Lambert, Craig
Laverty, Hugh G.
Naisbitt, Dean J.
Nelson, Sidney
Nicoll-Griffith, Deborah A.
Obach, R. Scott
Routledge, Philip
Smith, Dennis A.
Tweedie, Donald J.
Vermeulen, Nico
Williams, Dominic P.
Wilson, Ian D.
Baillie, Thomas A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1356925666
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1356925666
Other Identifiers
ISSN
1474-1776
E-ISSN
1474-1784
DOI
10.1038/nrd3408
