Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) down...
Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis
About this item
Full title
Author / Creator
Publisher
Netherlands
Journal title
Language
English
Formats
Publication information
Publisher
Netherlands
Subjects
More information
Scope and Contents
Contents
Shikonin derivatives exert powerful cytotoxic effects, induce apoptosis and escape multidrug resistance in cancer. However, the diverse mechanisms underlying their anticancer activities are not completely understood. Here, we demonstrated that shikonin-induced apoptosis is caused by reactive oxygen species (ROS)-mediated activation of Akt/ASK1/p38...
Alternative Titles
Full title
Reactive oxygen species-mediated activation of the Akt/ASK1/p38 signaling cascade and p21(Cip1) downregulation are required for shikonin-induced apoptosis
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1357492979
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1357492979
Other Identifiers
E-ISSN
1573-675X
DOI
10.1007/s10495-013-0835-5
