Increased Ornithine-Derived Polyamines Cause Airway Hyperresponsiveness in a Mouse Model of Asthma
Increased Ornithine-Derived Polyamines Cause Airway Hyperresponsiveness in a Mouse Model of Asthma
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Publisher
United States: American Thoracic Society
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Language
English
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Publisher
United States: American Thoracic Society
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Scope and Contents
Contents
Up-regulation of arginase contributes to airways hyperresponsiveness (AHR) in asthma by reducing L-arginine bioavailability for the nitric oxide (NO) synthase isozymes. The product of arginase activity, L-ornithine, can be metabolized into polyamines by ornithine decarboxylase. We tested the hypothesis that increases in L-ornithine-derived polyamin...
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Full title
Increased Ornithine-Derived Polyamines Cause Airway Hyperresponsiveness in a Mouse Model of Asthma
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Record Identifier
TN_cdi_proquest_miscellaneous_1365050916
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1365050916
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ISSN
1044-1549
E-ISSN
1535-4989
DOI
10.1165/rcmb.2012-0323OC
