Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca²⁺ release in a ge...
Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca²⁺ release in a genetic model of arrhythmia
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Contents
Dysregulated intracellular Ca²⁺ signaling is implicated in a variety of cardiac arrhythmias, including catecholaminergic polymorphic ventricular tachycardia. Spontaneous diastolic Ca²⁺ release (DCR) can induce arrhythmogenic plasma membrane depolarizations, although the mechanism responsible for DCR synchronization among adjacent myocytes required...
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Full title
Decreased RyR2 refractoriness determines myocardial synchronization of aberrant Ca²⁺ release in a genetic model of arrhythmia
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TN_cdi_proquest_miscellaneous_1370125956
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1370125956
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1300052110
