Single-stranded nucleic acids promote SAMHD1 complex formation
Single-stranded nucleic acids promote SAMHD1 complex formation
About this item
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Author / Creator
Publisher
Berlin/Heidelberg: Springer-Verlag
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer-Verlag
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Scope and Contents
Contents
SAM domain and HD domain-containing protein 1 (SAMHD1) is a dGTP-dependent triphosphohydrolase that degrades deoxyribonucleoside triphosphates (dNTPs) thereby limiting the intracellular dNTP pool. Mutations in SAMHD1 cause Aicardi–Goutières syndrome (AGS), an inflammatory encephalopathy that mimics congenital viral infection and that phenotypically...
Alternative Titles
Full title
Single-stranded nucleic acids promote SAMHD1 complex formation
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Record Identifier
TN_cdi_proquest_miscellaneous_1399904941
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1399904941
Other Identifiers
ISSN
0946-2716
E-ISSN
1432-1440
DOI
10.1007/s00109-013-0995-3
