Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral ass...
Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Lipid droplets have a key role in the assembly of hepatitis C virus (HCV) particles in liver cells. Jake Liang and colleagues now report that a host factor, IκB kinase-α is required for efficient production of HCV by increasing cellular lipid droplet content through its regulation of lipogenic genes in infected cells. The findings provide insight i...
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Hepatitis C virus infection activates an innate pathway involving IKK-α in lipogenesis and viral assembly
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TN_cdi_proquest_miscellaneous_1399914257
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1399914257
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3190
