Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pa...
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway: e1003487
About this item
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Author / Creator
Li, Gang , Diogo, Dorothée , Wu, Di , Spoonamore, Jim , Dancik, Vlado , Franke, Lude , Kurreeman, Fina , Rossin, Elizabeth J , Duclos, Grant , Hartland, Cathy , Zhou, Xuezhong , Li, Kejie , Liu, Jun , Jager, Philip LDe , Siminovitch, Katherine A , Zhernakova, Alexandra , Raychaudhuri, Soumya , Bowes, John , Eyre, Steve , Padyukov, Leonid , Gregersen, Peter K , Worthington, Jane , Gupta, Namrata , Clemons, Paul A , Stahl, Eli , Tolliday, Nicola and Plenge, Robert M
Publisher
San Francisco: Public Library of Science
Journal title
Language
English
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Publication information
Publisher
San Francisco: Public Library of Science
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More information
Scope and Contents
Contents
Although genetic and non-genetic studies in mouse and human implicate the CD40 pathway in rheumatoid arthritis (RA), there are no approved drugs that inhibit CD40 signaling for clinical care in RA or any other disease. Here, we sought to understand the biological consequences of a CD40 risk variant in RA discovered by a previous genome-wide associa...
Alternative Titles
Full title
Human Genetics in Rheumatoid Arthritis Guides a High-Throughput Drug Screen of the CD40 Signaling Pathway: e1003487
Authors, Artists and Contributors
Author / Creator
Diogo, Dorothée
Wu, Di
Spoonamore, Jim
Dancik, Vlado
Franke, Lude
Kurreeman, Fina
Rossin, Elizabeth J
Duclos, Grant
Hartland, Cathy
Zhou, Xuezhong
Li, Kejie
Liu, Jun
Jager, Philip LDe
Siminovitch, Katherine A
Zhernakova, Alexandra
Raychaudhuri, Soumya
Bowes, John
Eyre, Steve
Padyukov, Leonid
Gregersen, Peter K
Worthington, Jane
Gupta, Namrata
Clemons, Paul A
Stahl, Eli
Tolliday, Nicola
Plenge, Robert M
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1399923646
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1399923646
Other Identifiers
ISSN
1553-7390
E-ISSN
1553-7404
DOI
10.1371/journal.pgen.1003487
