Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence
Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence
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Venkatraman, Aparna , He, Xi C. , Thorvaldsen, Joanne L. , Sugimura, Ryohichi , Perry, John M. , Tao, Fang , Zhao, Meng , Christenson, Matthew K. , Sanchez, Rebeca , Yu, Jaclyn Y. , Peng, Lai , Haug, Jeffrey S. , Paulson, Ariel , Li, Hua , Zhong, Xiao-bo , Clemens, Thomas L. , Bartolomei, Marisa S. and Li, Linheng
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Contents
Maternal genomic imprinting is crucial for the maintenance of adult stem cells, which is accomplished by maintaining long-term haematopoietic stem cell quiescence.
Epigenetic control of adult stem cells
A new study by Linheng Li and colleagues investigates the effect of deletion of the H19 differentially methylated region (H19-DMR) in haemato...
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Full title
Maternal imprinting at the H19–Igf2 locus maintains adult haematopoietic stem cell quiescence
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TN_cdi_proquest_miscellaneous_1426510795
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1426510795
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12303
