Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis
Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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The E3 ubiquitin ligases that modify the kinase RIP2 downstream of the receptor Nod2 remain unclear. Moynagh and colleagues show that Pellino3 ubiquitinates RIP2 for Nod2-induced activation of the transcription factor NF-κB.
Mutations that result in loss of function of Nod2, an intracellular receptor for bacterial peptidoglycan, are associated w...
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Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis
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TN_cdi_proquest_miscellaneous_1426747581
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1426747581
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1529-2908
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1529-2916
DOI
10.1038/ni.2669
