Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
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Author / Creator
Kulis, Marta , Heath, Simon , Bibikova, Marina , Queirós, Ana C , Navarro, Alba , Clot, Guillem , Martínez-Trillos, Alejandra , Castellano, Giancarlo , Brun-Heath, Isabelle , Pinyol, Magda , Barberán-Soler, Sergio , Papasaikas, Panagiotis , Jares, Pedro , Beà, Sílvia , Rico, Daniel , Ecker, Simone , Rubio, Miriam , Royo, Romina , Ho, Vincent , Klotzle, Brandy , Hernández, Lluis , Conde, Laura , López-Guerra, Mónica , Colomer, Dolors , Villamor, Neus , Aymerich, Marta , Rozman, María , Bayes, Mónica , Gut, Marta , Gelpí, Josep L , Orozco, Modesto , Fan, Jian-Bing , Quesada, Víctor , Puente, Xose S , Pisano, David G , Valencia, Alfonso , López-Guillermo, Armando , Gut, Ivo , López-Otín, Carlos , Campo, Elías and Martín-Subero, José I
Publisher
New York: Nature Publishing Group US
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Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Contents
José Martin-Subero and colleagues report whole-genome bisulfite sequencing and methylome analysis of two CLLs and three B-cell subpopulations using high-density microarrays on 139 CLLs. They identify widespread hypomethylation in the gene body that is largely associated with intragenic enhancer elements.
We have extensively characterized the DNA...
Alternative Titles
Full title
Epigenomic analysis detects widespread gene-body DNA hypomethylation in chronic lymphocytic leukemia
Authors, Artists and Contributors
Author / Creator
Heath, Simon
Bibikova, Marina
Queirós, Ana C
Navarro, Alba
Clot, Guillem
Martínez-Trillos, Alejandra
Castellano, Giancarlo
Brun-Heath, Isabelle
Pinyol, Magda
Barberán-Soler, Sergio
Papasaikas, Panagiotis
Jares, Pedro
Beà, Sílvia
Rico, Daniel
Ecker, Simone
Rubio, Miriam
Royo, Romina
Ho, Vincent
Klotzle, Brandy
Hernández, Lluis
Conde, Laura
López-Guerra, Mónica
Colomer, Dolors
Villamor, Neus
Aymerich, Marta
Rozman, María
Bayes, Mónica
Gut, Marta
Gelpí, Josep L
Orozco, Modesto
Fan, Jian-Bing
Quesada, Víctor
Puente, Xose S
Pisano, David G
Valencia, Alfonso
López-Guillermo, Armando
Gut, Ivo
López-Otín, Carlos
Campo, Elías
Martín-Subero, José I
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1434021797
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1434021797
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.2443
