Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain inj...
Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury
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Author / Creator
Ji, Jing , Kline, Anthony E , Amoscato, Andrew , Samhan-Arias, Alejandro K , Sparvero, Louis J , Tyurin, Vladimir A , Tyurina, Yulia Y , Fink, Bruno , Manole, Mioara D , Puccio, Ava M , Okonkwo, David O , Cheng, Jeffrey P , Alexander, Henry , Clark, Robert S B , Kochanek, Patrick M , Wipf, Peter , Kagan, Valerian E and Bayır, Hülya
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The authors show that traumatic brain injury can induce peroxidation of cardiolipin, leading to accumulation of numerous oxygenated species and the induction of neuronal cell death. This accumulation of cardiolipin and the associated toxicity can be ameliorated by mitochondria-targeted delivery of an electron scavenger.
The brain contains a high...
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Full title
Lipidomics identifies cardiolipin oxidation as a mitochondrial target for redox therapy of brain injury
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TN_cdi_proquest_miscellaneous_1434023326
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1434023326
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ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/nn.3195
