Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNF alpha Release via RA...
Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNF alpha Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells. e72354
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Objective Mitochondrial transcription factor A (TFAM) is normally bound to and remains associated with mitochondrial DNA (mtDNA) when released from damaged cells. We hypothesized that TFAM, bound to mtDNA (or equivalent CpG-enriched DNA), amplifies TNF alpha release from TLR9-expressing plasmacytoid dendritic cells (pDCs) by engaging RAGE. Material...
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Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNF alpha Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells. e72354
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TN_cdi_proquest_miscellaneous_1439226775
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1439226775
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1932-6203
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10.1371/journal.pone.0072354
