The cancer biology of whole-chromosome instability
The cancer biology of whole-chromosome instability
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
One form of chromosome instability (CIN), the recurrent missegregation of whole chromosomes during cell division (W-CIN), leads to aneuploidy. Although W-CIN is a hallmark of most cancers, mutations in genes involved in chromosome segregation are exceedingly rare. We discuss an oncogene-induced mitotic stress model that provides a mechanistic frame...
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Full title
The cancer biology of whole-chromosome instability
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TN_cdi_proquest_miscellaneous_1443385164
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1443385164
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2012.616
