Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication
Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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The RING finger domain protein Uhrf1 is known to have an important role in DNA methylation pattern maintenance through the recruitment of the methyltransferase Dnmt1 to hemimethylated DNA sites: here, Uhrf1 is shown to act as a ubiquitin ligase for H3, an essential step in Dnmt1 recruitment.
Linking DNA methylation and replication
The RING fi...
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Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication
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TN_cdi_proquest_miscellaneous_1443426231
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1443426231
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12488
