VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA
VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
The highly persistent and often lethal human pathogen,
Mycobacterium tuberculosis
contains at least 88 toxin–antitoxin genes. More than half of these encode VapC PIN domain endoribonucleases that inhibit cell growth by unknown mechanisms. Here we show that VapC20 of
M. tuberculosis
inhibits translation by cleavage of the Sarcin–Ricin lo...
Alternative Titles
Full title
VapC20 of Mycobacterium tuberculosis cleaves the Sarcin–Ricin loop of 23S rRNA
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TN_cdi_proquest_miscellaneous_1459154456
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1459154456
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms3796
