Aging as Accelerated Accumulation of Somatic Variants: Whole-Genome Sequencing of Centenarian and Mi...
Aging as Accelerated Accumulation of Somatic Variants: Whole-Genome Sequencing of Centenarian and Middle-Aged Monozygotic Twin Pairs
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Full title
Author / Creator
Ye, Kai , Beekman, Marian , Lameijer, Eric-Wubbo , Zhang, Yanju , Moed, Matthijs H. , van den Akker, Erik B. , Deelen, Joris , Houwing-Duistermaat, Jeanine J. , Kremer, Dennis , Anvar, Seyed Yahya , Laros, Jeroen F. J. , Jones, David , Raine, Keiran , Blackburne, Ben , Potluri, Shobha , Long, Quan , Guryev, Victor , van der Breggen, Ruud , Westendorp, Rudi G. J. , ‘t Hoen, Peter A. C. , den Dunnen, Johan , van Ommen, Gert Jan B. , Willemsen, Gonneke , Pitts, Steven J. , Cox, David R. , Ning, Zemin , Boomsma, Dorret I. and Slagboom, P. Eline
Publisher
Cambridge, UK: Cambridge University Press
Journal title
Language
English
Formats
Publication information
Publisher
Cambridge, UK: Cambridge University Press
Subjects
More information
Scope and Contents
Contents
It has been postulated that aging is the consequence of an accelerated accumulation of somatic DNA mutations and that subsequent errors in the primary structure of proteins ultimately reach levels sufficient to affect organismal functions. The technical limitations of detecting somatic changes and the lack of insight about the minimum level of erro...
Alternative Titles
Full title
Aging as Accelerated Accumulation of Somatic Variants: Whole-Genome Sequencing of Centenarian and Middle-Aged Monozygotic Twin Pairs
Authors, Artists and Contributors
Author / Creator
Beekman, Marian
Lameijer, Eric-Wubbo
Zhang, Yanju
Moed, Matthijs H.
van den Akker, Erik B.
Deelen, Joris
Houwing-Duistermaat, Jeanine J.
Kremer, Dennis
Anvar, Seyed Yahya
Laros, Jeroen F. J.
Jones, David
Raine, Keiran
Blackburne, Ben
Potluri, Shobha
Long, Quan
Guryev, Victor
van der Breggen, Ruud
Westendorp, Rudi G. J.
‘t Hoen, Peter A. C.
den Dunnen, Johan
van Ommen, Gert Jan B.
Willemsen, Gonneke
Pitts, Steven J.
Cox, David R.
Ning, Zemin
Boomsma, Dorret I.
Slagboom, P. Eline
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1462186046
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1462186046
Other Identifiers
ISSN
1832-4274
E-ISSN
1839-2628
DOI
10.1017/thg.2013.73
