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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1490734710

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

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London: Nature Publishing Group UK

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Contents

Two small-molecule disruptors of the glucokinase–glucokinase-regulatory-protein complex, AMG-1694 and AMG-3969, are identified that decrease blood glucose levels in various models of hyperglycaemic rodents.
Novel glucose-lowering agents
Glucokinase (GK) is involved in the regulation of glucose homeostasis and is an important target for drug d...

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Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

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Record Identifier

TN_cdi_proquest_miscellaneous_1490734710

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1490734710

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature12724

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