CYP17 inhibitors—abiraterone, C17,20-lyase inhibitors and multi-targeting agents
CYP17 inhibitors—abiraterone, C17,20-lyase inhibitors and multi-targeting agents
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Key Points
17α-Hydroxylase/C17,20-lyase (CYP17) is a steroidogenic enzyme that is central to the production of androgens, and is targeted by abiraterone in men with castration-resistant prostate cancer
Abiraterone is a promiscuous drug, interacting with numerous targets that include CYP11B1 and a panel of hepatic CYP enzymes; these interactio...
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CYP17 inhibitors—abiraterone, C17,20-lyase inhibitors and multi-targeting agents
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TN_cdi_proquest_miscellaneous_1490763437
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1490763437
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ISSN
1759-4812
E-ISSN
1759-4820
DOI
10.1038/nrurol.2013.274
