Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors i...
Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice
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Author / Creator
Inagaki-Ohara, K , Mayuzumi, H , Kato, S , Minokoshi, Y , Otsubo, T , Kawamura, Y I , Dohi, T , Matsuzaki, G and Yoshimura, A
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Leptin acts on its receptor (ObR) in the hypothalamus to inhibit food intake and energy expenditure. Leptin and ObR are also expressed in the gastrointestinal tract; however, the physiological significance of leptin signaling in the gut remains uncertain. Suppressor of cytokine signaling 3 (SOCS3) is a key negative feedback regulator of ObR-mediate...
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Full title
Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice
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Record Identifier
TN_cdi_proquest_miscellaneous_1492622191
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1492622191
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ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2012.540
