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CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp13...

CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp13...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1492625586

CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Mueller glial cells

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Full title

CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Mueller glial cells

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2013-11, Vol.110 (47), p.E4520-E4520

Language

English

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Scope and Contents

Contents

Ciliary neurotrophic factor (CNTF) acts as a potent neuroprotective agent in multiple retinal degeneration animal models. Recently, CNTF has been evaluated in clinical trials for the inherited degenerative disease retinitis pigmentosa (RP) and for dry age-related macular degeneration (AMD). Despite its potential as a broad-spectrum therapeutic trea...

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Full title

CNTF-mediated protection of photoreceptors requires initial activation of the cytokine receptor gp130 in Mueller glial cells

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Record Identifier

TN_cdi_proquest_miscellaneous_1492625586

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1492625586

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ISSN

0027-8424

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