Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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The pathway causing CD4 T-cell death in HIV-infected hosts remains poorly understood although apoptosis has been proposed as a key mechanism. We now show that caspase-3-mediated apoptosis accounts for the death of only a small fraction of CD4 T cells corresponding to those that are both activated and productively infected. The remaining over 95% of...
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Full title
Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection
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TN_cdi_proquest_miscellaneous_1492693614
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1492693614
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12940
