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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

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Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1501377162

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

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London: Nature Publishing Group UK

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In acute myeloid leukaemia (AML), the cell of origin, nature and biological consequences of initiating lesions, and order of subsequent mutations remain poorly understood, as AML is typically diagnosed without observation of a pre-leukaemic phase. Here, highly purified haematopoietic stem cells (HSCs), progenitor and mature cell fractions from the...

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Full title

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

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Record Identifier

TN_cdi_proquest_miscellaneous_1501377162

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1501377162

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ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature13038

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