IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease...
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
About this item
Full title
Author / Creator
de Luca, Antonella , Smeekens, Sanne P. , Casagrande, Andrea , Iannitti, Rossana , Conway, Kara L. , Gresnigt, Mark. S. , Begun, Jakob , Plantinga, Theo S. , Joosten, Leo A. B. , van der Meer, Jos W. M. , Chamilos, Georgios , Netea, Mihai G. , Xavier, Ramnik J. , Dinarello, Charles A. , Romani, Luigina and van de Veerdonk, Frank L.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Patients with chronic granulomatous disease (CGD) have a mutated NADPH complex resulting in defective production of reactive oxygen species; these patients can develop severe colitis and are highly susceptible to invasive fungal infection. In NADPH oxidasedeficient mice, autophagy is defective but inflammasome activation is present despite lack of...
Alternative Titles
Full title
IL-1 receptor blockade restores autophagy and reduces inflammation in chronic granulomatous disease in mice and in humans
Authors, Artists and Contributors
Author / Creator
Smeekens, Sanne P.
Casagrande, Andrea
Iannitti, Rossana
Conway, Kara L.
Gresnigt, Mark. S.
Begun, Jakob
Plantinga, Theo S.
Joosten, Leo A. B.
van der Meer, Jos W. M.
Chamilos, Georgios
Netea, Mihai G.
Xavier, Ramnik J.
Dinarello, Charles A.
Romani, Luigina
van de Veerdonk, Frank L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1504739836
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1504739836
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1322831111
