Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dep...
Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation
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Author / Creator
Ito, K , Maruyama, Z , Sakai, A , Izumi, S , Moriishi, T , Yoshida, C A , Miyazaki, T , Komori, H , Takada, K , Kawaguchi, H and Komori, T
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cell proliferation and differentiation are closely coupled. However, we previously showed that overexpression of cyclin-dependent kinase (
Cdk6
) blocks chondrocyte differentiation without affecting cell-cycle progression
in vitro
. To investigate whether Cdk6 inhibits chondrocyte differentiation
in vivo
, we generated chondrocyte...
Alternative Titles
Full title
Overexpression of Cdk6 and Ccnd1 in chondrocytes inhibited chondrocyte maturation and caused p53-dependent apoptosis without enhancing proliferation
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1516756634
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1516756634
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/onc.2013.130
