Influence of two different doses of antithymocyte globulin in patients with standard-risk disease fo...
Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation: a randomized trial
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Wang, Y , Fu, H-X , Liu, D-H , Xu, L-P , Zhang, X-H , Chang, Y-J , Chen, Y-H , Wang, F-R , Sun, Y-Q , Tang, F-F , Liu, K-Y and Huang, X-J
Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
To evaluate the effect of the different doses of antithymocyte globulin (ATG) on the incidence of acute GVHD among patients receiving hematopoietic SCT without
ex vivo
T-cell-depletion from haploidentical donors, 224 patients with standard-risk hematological malignancy were randomized in this study. One hundred and twelve patients received 6 mg/kg ATG, whereas the remaining patients received 10 mg/kg ATG. This study was registered at
http://www.chictr.org
as No. ChiCTR-TRC-11001761. The incidence of grade III–IV acute GVHD was higher in the ATG-6 group (16.1%, 95% confidence interval (CI), 9.1–23.1%) than in the ATG-10 group (4.5%, CI, 0.7–8.3%,
P
=0.005, 95% CI for the difference, −19.4% to −3.8%). EBV reactivation occurred more frequently in the ATG-10 group (25.3%, 17.1–33.5%) than...
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Full title
Influence of two different doses of antithymocyte globulin in patients with standard-risk disease following haploidentical transplantation: a randomized trial
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TN_cdi_proquest_miscellaneous_1524416622
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1524416622
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ISSN
0268-3369
E-ISSN
1476-5365
DOI
10.1038/bmt.2013.191
