Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia...
Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure
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New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Retinoic acid and arsenic therapies have shown considerable efficacy in patients with acute promyelocytic leukemia, but their exact mechanism of action remains unclear. Here, Hugues de Thé and colleagues uncover a therapeutic effect mediated by nuclear body reformation and p53 activation that involves the induction of a senescence transcriptional p...
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Full title
Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure
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TN_cdi_proquest_miscellaneous_1534850015
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1534850015
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ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3441
