Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma
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Author / Creator
Lim, Weng Khong , Ong, Choon Kiat , Tan, Jing , Thike, Aye Aye , Ng, Cedric Chuan Young , Rajasegaran, Vikneswari , Myint, Swe Swe , Nagarajan, Sanjanaa , Nasir, Nur Diyana Md , McPherson, John R , Cutcutache, Ioana , Poore, Gregory , Tay, Su Ting , Ooi, Wei Siong , Tan, Veronique Kiak Mien , Hartman, Mikael , Ong, Kong Wee , Tan, Benita K T , Rozen, Steven G , Tan, Puay Hoon , Tan, Patrick and Teh, Bin Tean
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Bin Tean Teh and colleagues report exome sequencing of 8 breast fibroadenomas and follow-up targeted sequencing in 90 additional samples. They find that 59% of samples contain somatic mutations in exon 2 of
MED12
, a mutational pattern shared with another female-specific benign tumor, uterine leiomyoma.
Fibroadenomas are the most common br...
Alternative Titles
Full title
Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma
Authors, Artists and Contributors
Author / Creator
Ong, Choon Kiat
Tan, Jing
Thike, Aye Aye
Ng, Cedric Chuan Young
Rajasegaran, Vikneswari
Myint, Swe Swe
Nagarajan, Sanjanaa
Nasir, Nur Diyana Md
McPherson, John R
Cutcutache, Ioana
Poore, Gregory
Tay, Su Ting
Ooi, Wei Siong
Tan, Veronique Kiak Mien
Hartman, Mikael
Ong, Kong Wee
Tan, Benita K T
Rozen, Steven G
Tan, Puay Hoon
Tan, Patrick
Teh, Bin Tean
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1549632304
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1549632304
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3037
