Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type...
Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
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United States
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Language
English
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United States
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Type I interferon (IFN) protects against viruses, yet it also has a poorly understood suppressive influence on inflammation. Here, we report that activated mouse macrophages lacking the IFN-stimulated gene cholesterol 25-hydroxylase (Ch25h) and that are unable to produce the oxysterol 25-hydroxycholesterol (25-HC) overproduce inflammatory interleuk...
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Full title
Inflammation. 25-Hydroxycholesterol suppresses interleukin-1-driven inflammation downstream of type I interferon
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TN_cdi_proquest_miscellaneous_1552375967
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1552375967
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E-ISSN
1095-9203
DOI
10.1126/science.1254790
