YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-depend...
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression
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Author / Creator
Gao, Yijun , Zhang, Wenjing , Han, Xiangkun , Li, Fuming , Wang, Xujun , Wang, Rui , Fang, Zhaoyuan , Tong, Xinyuan , Yao, Shun , Li, Fei , Feng, Yan , Sun, Yihua , Hou, Yingyong , Yang, Zhongzhou , Guan, Kunliang , Chen, Haiquan , Zhang, Lei and Ji, Hongbin
Publisher
London: Nature Publishing Group UK
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English
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Publisher
London: Nature Publishing Group UK
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Contents
Whether the Hippo pathway contributes to cell lineage transition under pathological conditions, especially tumorigenesis, remains largely unknown. Here we show that YAP, the major effector of the Hippo pathway, displays a distinct activation pattern in lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC); YAP is initially activated by LKB1 l...
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Full title
YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression
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TN_cdi_proquest_miscellaneous_1553323577
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1553323577
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms5629
