Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment...
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Lewy bodies and Lewy neurites are found in the brains of patients with Parkinson's disease and other synucleinopathies. This protocol describes how to model this by inducing α-synuclein aggregates in a primary neuronal culture system.
This protocol describes a primary neuronal model of formation of α-synuclein (α-syn) aggregates that recapitulat...
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Full title
Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
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TN_cdi_proquest_miscellaneous_1553709159
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1553709159
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ISSN
1754-2189
E-ISSN
1750-2799
DOI
10.1038/nprot.2014.143
