A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site
A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site
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New York: Nature Publishing Group US
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Language
English
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New York: Nature Publishing Group US
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Contents
A small-molecule compound, GSK2194069, specifically inhibits the β-ketoacyl reductase (KR) activity of the human fatty acid synthase. A co-crystal structure of the KR domain with the inhibitor confirms this interaction.
Human fatty acid synthase (hFAS) is a complex, multifunctional enzyme that is solely responsible for the
de novo
synthesi...
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Full title
A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site
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TN_cdi_proquest_miscellaneous_1554940626
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1554940626
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1603
