Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling
Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling
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United States: American Association for the Advancement of Science
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English
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United States: American Association for the Advancement of Science
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Mitochondrial morphology is crucial for tissue homeostasis, but its role in cell differentiation is unclear. We found that mitochondrial fusion was required for proper cardiomyocyte development. Ablation of mitochondrial fusion proteins Mitofusin 1 and 2 in the embryonic mouse heart, or gene-trapping of Mitofusin 2 or Optic atrophy 1 in mouse embry...
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Mitochondrial Fusion Directs Cardiomyocyte Differentiation via Calcineurin and Notch Signaling
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TN_cdi_proquest_miscellaneous_1559675136
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1559675136
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ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1241359
