Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial
Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial
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for the HARMONY I study group , HARMONY I study group , Dauvilliers, Yves, Prof , Bassetti, Claudio, Prof , Lammers, Gert Jan, Prof , Arnulf, Isabelle, Prof , Mayer, Geert, Prof , Rodenbeck, Andrea, Prof , Lehert, Philippe, Prof , Ding, Claire-Li , Lecomte, Jeanne-Marie, PhD and Schwartz, Jean-Charles, Prof
Publisher
England: Elsevier Ltd
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English
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England: Elsevier Ltd
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Summary Background Narcolepsy is characterised by excessive daytime sleepiness (EDS) and cataplexy. Histamine neurons are crucial to maintain wakefulness. We assessed the safety and efficacy of pitolisant (previously called BF2.649), a selective histamine H3 receptor inverse agonist that activates these neurons, in patients with narcolepsy. Methods...
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Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial
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TN_cdi_proquest_miscellaneous_1560104548
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1560104548
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ISSN
1474-4422
E-ISSN
1474-4465
DOI
10.1016/S1474-4422(13)70225-4
