Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency: e107...
Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency: e107241
About this item
Full title
Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency: e107241
Author / Creator
Journal title
PloS one, 2014-09, Vol.9 (9)
Language
English
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Scope and Contents
Contents
Single nucleotide polymorphisms (SNPs) in the FK506 binding protein 5 (FKBP5) gene combine with traumatic events to increase risk for post-traumatic stress and major depressive disorders (PTSD and MDD). These SNPs increase FKBP51 protein expression through a mechanism involving demethylation of the gene and altered glucocorticoid signaling. Aged an...
Alternative Titles
Full title
Age-Associated Epigenetic Upregulation of the FKBP5 Gene Selectively Impairs Stress Resiliency: e107241
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Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1566835493
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1566835493
Other Identifiers
E-ISSN
1932-6203
DOI
10.1371/journal.pone.0107241
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