The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP ge...
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression
About this item
Full title
Author / Creator
Whissell, Gavin , Montagni, Elisa , Martinelli, Paola , Hernando-Momblona, Xavier , Sevillano, Marta , Jung, Peter , Cortina, Carme , Calon, Alexandre , Abuli, Anna , Castells, Antoni , Castellvi-Bel, Sergi , Nacht, Ana Silvina , Sancho, Elena , Stephan-Otto Attolini, Camille , Vicent, Guillermo P. , Real, Francisco X. and Batlle, Eduard
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Aberrant activation of WNT signalling and loss of BMP signals represent the two main alterations leading to the initiation of colorectal cancer (CRC). Here we screen for genes required for maintaining the tumour stem cell phenotype and identify the zinc-finger transcription factor GATA6 as a key regulator of the WNT and BMP pathways in CRC. GATA6 d...
Alternative Titles
Full title
The transcription factor GATA6 enables self-renewal of colon adenoma stem cells by repressing BMP gene expression
Authors, Artists and Contributors
Author / Creator
Montagni, Elisa
Martinelli, Paola
Hernando-Momblona, Xavier
Sevillano, Marta
Jung, Peter
Cortina, Carme
Calon, Alexandre
Abuli, Anna
Castells, Antoni
Castellvi-Bel, Sergi
Nacht, Ana Silvina
Sancho, Elena
Stephan-Otto Attolini, Camille
Vicent, Guillermo P.
Real, Francisco X.
Batlle, Eduard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1566840882
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1566840882
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2992
