Involvement of the Cyclin-Dependent Kinase Inhibitor p16 (INK4a) in Replicative Senescence of Normal...
Involvement of the Cyclin-Dependent Kinase Inhibitor p16 (INK4a) in Replicative Senescence of Normal Human Fibroblasts
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United States: National Academy of Sciences of the United States of America
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English
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United States: National Academy of Sciences of the United States of America
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Human diploid fibroblasts (HDFs) can be grown in culture for a finite number of population doublings before they cease proliferation and enter a growth-arrest state termed replicative senescence. The retinoblastoma gene product, Rb, expressed in these cells is hypophosphorylated. To determine a possible mechanism by which senescent human fibroblast...
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Full title
Involvement of the Cyclin-Dependent Kinase Inhibitor p16 (INK4a) in Replicative Senescence of Normal Human Fibroblasts
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TN_cdi_proquest_miscellaneous_15783714
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_15783714
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.93.24.13742
