Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-depen...
Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Dendritic cells (DCs) orchestrate antibody-mediated responses to combat extracellular pathogens including parasites by initiating T helper cell differentiation. Here we demonstrate that carbohydrate-specific signalling by DC-SIGN drives follicular T helper cell (T
FH
) differentiation via IL-27 expression. Fucose, but not mannose, engagement...
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Full title
Fucose-based PAMPs prime dendritic cells for follicular T helper cell polarization via DC-SIGN-dependent IL-27 production
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TN_cdi_proquest_miscellaneous_1586094520
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1586094520
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ISSN
2041-1723
E-ISSN
2041-1723
DOI
10.1038/ncomms6074
