X-Ray Analysis of Azido-Thymidine Diphosphate Binding to Nucleoside Diphosphate Kinase
X-Ray Analysis of Azido-Thymidine Diphosphate Binding to Nucleoside Diphosphate Kinase
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Publisher
United States: National Academy of Sciences of the United States of America
Journal title
Language
English
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Publisher
United States: National Academy of Sciences of the United States of America
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Contents
To be effective as antiviral agent, AZT (3′-azido-3′-deoxythymidine) must be converted to a triphosphate derivative by cellular kinases. The conversion is inefficient and, to understand why AZT diphosphate is a poor substrate of nucleoside diphosphate (NDP) kinase, we determined a 2.3- angstrom x-ray structure of a complex with the N119A point muta...
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Full title
X-Ray Analysis of Azido-Thymidine Diphosphate Binding to Nucleoside Diphosphate Kinase
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Record Identifier
TN_cdi_proquest_miscellaneous_16017713
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_16017713
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.94.14.7162
