PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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SUZ12, a component of the PRC2 complex, can also function as a tumour suppressor in certain tumours of the nervous system and melanomas.
Interaction of PRC2 with Ras pathway
The PRC2 complex, which regulates gene expression through chromatin modification, has been shown to play a pro-tumorigenic role in many tumours. Karen Cichowski and colle...
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PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies
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TN_cdi_proquest_miscellaneous_1610757512
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1610757512
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0028-0836,1476-4687
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1476-4687
DOI
10.1038/nature13561
