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Human Adenovirus-Specific gamma / delta and CD8+ T Cells Generated by T-Cell Receptor Transfection t...

Human Adenovirus-Specific gamma / delta and CD8+ T Cells Generated by T-Cell Receptor Transfection t...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1618148824

Human Adenovirus-Specific gamma / delta and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation: e109944

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Full title

Human Adenovirus-Specific gamma / delta and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation: e109944

Journal title

PloS one, 2014-10, Vol.9 (10)

Language

English

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Scope and Contents

Contents

Human adenovirus infection is life threatening after allogeneic haematopoietic stem cell transplantation (HSCT). Immunotherapy with donor-derived adenovirus-specific T cells is promising; however, 20% of all donors lack adenovirus-specific T cells. To overcome this, we transfected alpha / beta T cells with mRNA encoding a T-cell receptor (TCR) spec...

Alternative Titles

Full title

Human Adenovirus-Specific gamma / delta and CD8+ T Cells Generated by T-Cell Receptor Transfection to Treat Adenovirus Infection after Allogeneic Stem Cell Transplantation: e109944

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Primary Identifiers

Record Identifier

TN_cdi_proquest_miscellaneous_1618148824

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1618148824

Other Identifiers

E-ISSN

1932-6203

DOI

10.1371/journal.pone.0109944

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