Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and...
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
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Author / Creator
Dowdle, William E. , Nyfeler, Beat , Nagel, Jane , Elling, Robert A. , Liu, Shanming , Triantafellow, Ellen , Menon, Suchithra , Wang, Zuncai , Honda, Ayako , Pardee, Gwynn , Cantwell, John , Luu, Catherine , Cornella-Taracido, Ivan , Harrington, Edmund , Fekkes, Peter , Lei, Hong , Fang, Qing , Digan, Mary Ellen , Burdick, Debra , Powers, Andrew F. , Helliwell, Stephen B. , D’Aquin, Simon , Bastien, Julie , Wang, Henry , Wiederschain, Dmitri , Kuerth, Jenny , Bergman, Philip , Schwalb, David , Thomas, Jason , Ugwonali, Savuth , Harbinski, Fred , Tallarico, John , Wilson, Christopher J. , Myer, Vic E. , Porter, Jeffery A. , Bussiere, Dirksen E. , Finan, Peter M. , Labow, Mark A. , Mao, Xiaohong , Hamann, Lawrence G. , Manning, Brendan D. , Valdez, Reginald A. , Nicholson, Thomas , Schirle, Markus , Knapp, Mark S. , Keaney, Erin P. and Murphy, Leon O.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Cells rely on autophagy to clear misfolded proteins and damaged organelles to maintain cellular homeostasis. In this study we use the new autophagy inhibitor PIK-III to screen for autophagy substrates. PIK-III is a selective inhibitor of VPS34 that binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kα. PIK-III acutely inh...
Alternative Titles
Full title
Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo
Authors, Artists and Contributors
Author / Creator
Nyfeler, Beat
Nagel, Jane
Elling, Robert A.
Liu, Shanming
Triantafellow, Ellen
Menon, Suchithra
Wang, Zuncai
Honda, Ayako
Pardee, Gwynn
Cantwell, John
Luu, Catherine
Cornella-Taracido, Ivan
Harrington, Edmund
Fekkes, Peter
Lei, Hong
Fang, Qing
Digan, Mary Ellen
Burdick, Debra
Powers, Andrew F.
Helliwell, Stephen B.
D’Aquin, Simon
Bastien, Julie
Wang, Henry
Wiederschain, Dmitri
Kuerth, Jenny
Bergman, Philip
Schwalb, David
Thomas, Jason
Ugwonali, Savuth
Harbinski, Fred
Tallarico, John
Wilson, Christopher J.
Myer, Vic E.
Porter, Jeffery A.
Bussiere, Dirksen E.
Finan, Peter M.
Labow, Mark A.
Mao, Xiaohong
Hamann, Lawrence G.
Manning, Brendan D.
Valdez, Reginald A.
Nicholson, Thomas
Schirle, Markus
Knapp, Mark S.
Keaney, Erin P.
Murphy, Leon O.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_1619318370
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1619318370
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb3053
