Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs
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United States: Nature Publishing Group
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English
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United States: Nature Publishing Group
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Agonists of mouse STING (TMEM173) shrink and even cure solid tumors by activating innate immunity; human STING (hSTING) agonists are needed to test this therapeutic hypothesis in humans. The endogenous STING agonist is 2'3'-cGAMP, a second messenger that signals the presence of cytosolic double-stranded DNA. We report activity-guided partial purifi...
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Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs
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TN_cdi_proquest_miscellaneous_1625340873
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_1625340873
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ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/nchembio.1661
